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http://ciatej.repositorioinstitucional.mx/jspui/handle/1023/612| Antihypertensive effect of Justicia spicigera in L-NAME-induced hypertensive rats | |
| EDGAR ROMUALDO ESQUIVEL GUTIERREZ RUTH NORIEGA CISNEROS MELCHOR ARELLANO PLAZA MAXIMILIANO IBARRA BARAJAS Rafael Salgado Garciglia FRANCISCO ALFREDO SAAVEDRA MOLINA | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| "The cardiovascular disorder of hypertension is one of the main non-communicable diseases worldwide, and is responsible for over 80% of the deaths in low- and middle-income countries. Justicia spicigera (muicle) is a plant used in Mexican traditional medicine for the treatment of various disorders, including hypertension. The principle aim of this work was to evaluate the effects on blood pressure of different extracts taken from the aerial parts of the muicle plant Justicia spicigera (Acanthaceae). To the best of our knowledge there are no such previous reports. For the purpose of this study, the extracts were applied in hypertensive L-NAME Wistar rats. The results show that hexane and methanol extracts did not lower blood pressure and the aqueous extract only decreased the diastolic blood pressure (from 163/148 ± 6.65/6.64 mmHg to 156/128 ± 11.8/4.51 mmHg) in the hypertensive rats, but not in the normotensive animals. However, the chloroform extract lowered the arterial blood pressure (180/164 ± 1.7/3.2 mmHg) to values similar to those of the normotensive rats (149/133 ± 4.0/3.7 mmHg). The extracts had no effect on the control animals and the vehicles did not modify arterial blood pressure in any of the animals. Finally, the chloroform extract of aerial parts of J. spicigera was further analyzed by high performance liquid chromatography (HPLC) to identify and quantify major bioactive flavonoid compounds profile. As revealed by the results, the chloroform extract yielded three major flavonoid compounds, identified as hesperidin, naringenin and kaempferol, metabolites that could be responsible of antihypertensive effects of J. spicigera." | |
| 30-08-2013 | |
| Artículo | |
| Pharmacology On Line ISSN:1827-8620), Archives 2013-Vol. 2 Pp 120-127 | |
| Inglés | |
| BIOLOGÍA Y QUÍMICA | |
| Aparece en las colecciones: | ARTICULOS |
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| PhOL_2013_2_A017_014_Esquivel_Gutierrez.pdf | 653.29 kB | Adobe PDF | Visualizar/Abrir |