Please use this identifier to cite or link to this item: http://ciatej.repositorioinstitucional.mx/jspui/handle/1023/657
Mycobacterium tuberculosis TLR-2 agonists LprA, LM and Man-LAM induce notch1 and socs3 transcription
MARIO ALBERTO FLORES VALDEZ
VANIA ELVIRA BONIFAZ PENA
ERIKA NAHOMY MARINO MARMOLEJO
CITLALLI TORNEZ BENITEZ
Mabel Guzmán Rodríguez
Abel Gutiérrez Ortega
Letícia Santos
HUGO ENRIQUE LOPEZ GONZALEZ
Acceso Abierto
Atribución-NoComercial-SinDerivadas
1996-0808
"Mycobacterium tuberculosis employs a number of strategies to subvert host signaling events, leading to its persistence within macrophages. Upon infection, Mycobacterium bovis BCG induce the expression of suppressor of cytokine signaling 3 (socs3), in a Toll-like receptor 2 (TLR2)-Notch1- dependent manner. Purified phosphatidyl inositol di-mannosides (a TLR2 agonist) act as an inducer for the Notch1-socs3 pathway. This prompted us to analyze other TLR2 agonists seeking for additional molecules that may affect this pathway. We found that lipoprotein LprA, as well as glycolipids lipomannan (LM), and mannose-capped lipoarabinomannan (ManLAM) treatment of murine macrophages resulted in stimulation of notch1 and socs3 transcription".
Academic Journals
2011
Artículo
African Journal of Microbiology Research Vol. 5(15), pp. 2168-2172, 4 August, 2011
Inglés
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Marino-Marmolejo, E. N., Tornez-Benítez, C., Bonifaz-Pentilde, V. E., Guzmán-Rodríguez, M., López-González, H. E., Gutierrez-Ortega, A., ... & Flores-Valdez, M. A. (2011). Mycobacterium tuberculosis TLR2 agonists LprA, LM and Man-LAM induce notch1 and socs3 transcription. African Journal of Microbiology Research, 5(15), 2168-2172.
BIOLOGÍA Y QUÍMICA
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