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http://ciatej.repositorioinstitucional.mx/jspui/handle/1023/697| Apoptosis induction of agave lechuguilla torrey extract on human lung adenocarcinoma cells (SK-LU-1) | |
| LUIS ALBERTO ANGUIANO SEVILLA CYNTHIA ORDAZ PICHARDO JORGE LUIS ROSAS TRIGUEROS María Eugenia Jaramillo Flores EUGENIA DEL CARMEN LUGO CERVANTES | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.3390/ijms19123765 | |
| "In this study, an ethanol extract of Agave lechuguilla was evaluated against six carcinogenic cell lines (HCT-15, MCF-7, PC-3, U-251, SK-LU-1 and K-562) with an inhibition of 75.7 ± 2.3% against the SK-LU-1 line. Based on the previous result, the extract was hydrolyzed and fractionated, to which the IC50 was determined; the cell line was more sensitive to the fractionated extract with an IC50 6.96 ± 0.15 µg/mL. Characterization by mass spectrometry showed the presence of kaempferol, quercetin and a flavonoid dimer formed by afzelechin-4β-8-quercetin, according to the generated fragmentation pattern. The fractionated extract presented cell death by apoptosis with 39.8% at 24 h. Molecular docking was performed with the molecules found to try to describe cell death by apoptosis through death receptors such as FasCD95, TNF-R1, DR4/5 and blocking signaling on the EGFR and K-Ras MAPK/ERK pathway, as well as through the intrinsic pathway activating tBID, which promotes the amplification of the apoptotic signal due to the activation of caspase-3, and consequently caspase-7. In addition to the activation of the IIb complex associated with cell death due to necroptosis." | |
| MDPI | |
| 2018-11 | |
| Artículo | |
| International Journal Molecular Sciences 2018, 19, 3765 | |
| Inglés | |
| Bibliotecarios Estudiantes Investigadores | |
| Anguiano-Sevilla, L. A., Lugo-Cervantes, E., Ordaz-Pichardo, C., Rosas-Trigueros, J. L., & Jaramillo-Flores, M. E. (2018). Apoptosis Induction of Agave lechuguilla Torrey Extract on Human Lung Adenocarcinoma Cells (SK-LU-1). International journal of molecular sciences, 19(12), 3765. | |
| CIENCIAS AGROPECUARIAS Y BIOTECNOLOGÍA | |
| Aparece en las colecciones: | ARTICULOS |
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| ijms-19-03765.pdf | 2.87 MB | Adobe PDF | Visualizar/Abrir |