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http://ciatej.repositorioinstitucional.mx/jspui/handle/1023/797| Challenges for the development of dengue and zika virus vaccines | |
| Abel Gutiérrez Ortega DARWIN EDUARDO ELIZONDO QUIROGA | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| DOI: 10.26717/BJSTR.2018.08.001653 | |
| "Dengue (DENV) and Zika virus (ZIKV) are very close relatives belonging to the Flavivirus family and thus share many structural and antigenic features, as well as their infectious cycle. Both viruses are transmitted to humans through mosquito bites mainly from Aedes genus (Ae. aegypti and Ae. albopictus) [1], which have been expanded their habitats to an extent that half the World’s population is now at risk of DENV/ZIKV infection. The most severe consequences of having either virus would be dengue shock syndrome which normally leads to death [2], or in the case of ZIKV, microcephaly in newborns from infected mothers and GillianBarré syndrome [3-4]. For DENV, it has been well documented that a second infection with a different serotype, increases the chance of having the most severe dengue form, through a mechanism called antibody-dependent enhancement (ADE) [5], a phenomenon which has not been related in ZIKV infection in patients previously exposed to DENV or other Flaviviruses [6]. The fatal consequences, along with the lack of an effective treatment, have pushed forward a great effort from several research groups to develop vaccines against DENV, and it seems that some key learnings from DENV have accelerated the development for ZIKV vaccines". | |
| Biomedical Journal of Scientific & Technical Research (BJSTR) | |
| 2018-08 | |
| Artículo | |
| Biomedical Journal of Scientific & Technical Research (BJSTR) | |
| Inglés | |
| Bibliotecarios Estudiantes Investigadores Maestros | |
| MEDICINA Y CIENCIAS DE LA SALUD | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | ARTICULOS |
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