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http://ciatej.repositorioinstitucional.mx/jspui/handle/1023/828| Vaccine Impact on Glycosylation Evolution of Influenza A H1N1 | |
| HILDA EUGENIA LOPEZ GONZALEZ DARWIN EDUARDO ELIZONDO QUIROGA ERIKA NAHOMY MARINO MARMOLEJO FLOR YOHANA FLORES HERNANDEZ Jorge Bravo Madrigal | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| :10.31021/ctvv.20192107 | |
| "Influenza is a viral infection that causes annual epidemics, besides the latent risk of a possible pandemic. Nowadays the best choice to control influenza is vaccination. However vaccine effectiveness oscillates between 30 and 60%, it is inconvenient and must be reformulated every year, because of the high rate of mutability of the influenza virus. On the other hand, vaccinated population has caused the virus to undergo immunological pressure, causing mutations to escape. The principal target of this immunological pressure is due to the presence of glycoproteins on the viral surface, in where there are some well characterized antigenic sites. In the present study, hemagglutinin sequences from Influenza A/H1N1 from the last ten years were analyzed focusing on appearing and disappearing of N-glycosylation sites. As per previous reports, conserved glycosylation sites were identified, mostly on the stalk, other glycosites where found on the globular domain, such as the site 179, which in less than 10 years went from a very low rate, to be present in almost all the sequences, but, apparently this site is still undergoing through a stabilization phase, the main evidence, are the recent mutations that have arisen in the sequon. We discuss the possible repercussions that this could have on the choice of vaccine strains, and the impact of the substrate in where vaccines are developed and how this could be fundamental in their effectiveness". | |
| Boffin Access Limited | |
| 05-01-2019 | |
| Artículo | |
| Current Trends in Vaccines and Vaccinology Volume: 2.1 | |
| Inglés | |
| Bibliotecarios Empresas Investigadores Maestros | |
| López-González HE, Elizondo-Quiroga DE, Marino-Marmolejo EN, Flores-Hernández FY, Bravo-Madrigal J. Vaccine on glycosylation impact evolution of influenza A H1N1. Curr Trends Vaccine Vaccinol. 2019 Jan;2(1):107 | |
| MEDICINA Y CIENCIAS DE LA SALUD | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | ARTICULOS |
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| CTVV-2-107.pdf | 1.51 MB | Adobe PDF | Visualizar/Abrir |