Por favor, use este identificador para citar o enlazar este ítem:
http://ciatej.repositorioinstitucional.mx/jspui/handle/1023/867| Smilax aristolochiifolia Root Extract and Its Compounds Chlorogenic Acid and Astilbin Inhibit the Activity of α-Amylase and α-Glucosidase Enzymes | |
| Luis Antonio Salazar Olivo CARMEN LIZETTE DEL TORO SANCHEZ SERGIO NEMORIO HIDALGO FIGUEROA Janet Alejandra Gutiérrez Uribe MARILENA ANTUNES RICARDO VIRIDIANA CANDELARIA PEREZ NAJERA EUGENIA DEL CARMEN LUGO CERVANTES | |
| Acceso Abierto | |
| Atribución-NoComercial-SinDerivadas | |
| https://doi.org/10.1155/2018/6247306 | |
| "Regulating activities of α-amylase and α-glucosidase through the use of specifc inhibitors is a main strategy for controlling type 2 diabetes. Smilax aristolochiifolia root decoctions are traditionally used in Mexico as hypoglycemic and for weight loss, but the active principles and mechanisms underlying such putative metabolic efects are yet unknown. Here, we isolated the major bioactive compounds from a hydroethanolic extract of S. aristolochiifolia root by fast centrifugal partition chromatography and evaluated their efects against pancreatic α-amylase and yeast α-glucosidase. A chlorogenic acid-rich fraction (CAF) inhibited α-amylase activity with an IC50 value of 59.28 μg/mL in an uncompetitive manner and α-glucosidase activity with an IC50 value of 9.27 μg/mL in a noncompetitive mode. Also, an astilbin-rich fraction (ABF) inhibited α-glucosidase activity with an IC50 value of 12.30 μg/mL, in a noncompetitive manner. CAF inhibition α-amylase was as active as acarbose while both CAF and ABF were 50-fold more potent inhibitors of α-glucosidase than acarbose. Te molecular docking results of chlorogenic acid and astilbin with α-amylase and α-glucosidase enzymes correlated with the inhibition mechanisms suggested by enzymatic assays. Our results prove that S. aristolochiifolia roots contain chlorogenic acid and astilbin, which inhibit carbohydrates-hydrolyzing enzymes, suggesting a new mechanism for the hypoglycemic efect reported for this plant." | |
| 25-06-2018 | |
| Artículo | |
| Hindawi Evidence-Based Complementary and Alternative Medicine Volume 2018, Article ID 6247306, 12 pages | |
| Inglés | |
| Bibliotecarios Empresas Estudiantes Investigadores | |
| Pérez-Nájera, V. C., Gutiérrez-Uribe, J. A., Antunes-Ricardo, M., Hidalgo-Figueroa, S., Del-Toro-Sánchez, C. L., Salazar-Olivo, L. A., & Lugo-Cervantes, E. (2018). Smilax aristolochiifolia Root Extract and Its Compounds Chlorogenic Acid and Astilbin Inhibit the Activity of α-Amylase and α-Glucosidase Enzymes. Evidence-based complementary and alternative medicine : eCAM, 2018, 6247306. https://doi.org/10.1155/2018/6247306 | |
| BIOLOGÍA Y QUÍMICA | |
| Versión publicada | |
| publishedVersion - Versión publicada | |
| Aparece en las colecciones: | ARTICULOS |
Cargar archivos:
| Fichero | Tamaño | Formato | |
|---|---|---|---|
| Smilax.pdf | 3.3 MB | Adobe PDF | Visualizar/Abrir |